Saturday 11 January 2014

Clotting Factors

Clotting factors are substances in the blood that act in sequence to stop bleeding by forming a clot.


Here's a mnemonic to help you remember them ^___^

Clotting factors mnemonic
I Fibrinogen
II Prothrombin
III Tissue factor
IV Calcium
V Proaccelerin, Labile factor
VI  Unassigned – Old name of Factor Va 
VII Stable factor, proconvertin
VIII Antihemophilic factor A
IX Antihemophilic factor B or Christmas factor
X Stuart-Prower factor
XI Plasma thromboplastin antecedent
XII Hageman factor
XIII Fibrin-stabilizing factor

Mnemonics:
"Fresher's Party Tonight, Come Let's Sing And Call Seniors, Please Have Fun"

"Foolish People Try Climbing Long Slopes After Christmas, Some People Have Fallen"

"Fit Pants, Tight Collars, Loose American Shirts Are Cool Says Pretty Heroine Farah"

My favorite mnemonic is the pretty heroine one.. I drew it too :P
Sunglasses = Cool ;)

Here is how you draw the coagulation cascade:


Intrinsic pathway is activated bysubendothelial collagen.
Extrinsic pathway is activated by tissue thromboplastin.

Another mnemonic:
1972 WEPT

1972: Factors 10, 9, 7 & 2
W: Warfarin
E: Extrinsic
PT: Prothrombin Time

Factors X, IX, VII, II are Vitamin K dependent.
Warfarin acts on extrinsic pathway,prothrombin time used to check it.

If you know this, the other one is the other one.
Heparin acts on intrinsic pathway, partial thromboplastin time is used to check it.



Here is one for hemophilia.
Remember in hemophilia, bleeding time is normal, PTT is increased.

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