Aberations in the Normal Development and Involution of the breast (ANDI)
ANDI is a term used to describe most benign breast diseases
- based on the fact that most benign breast disorders are relatively minor aberrations of the normal processes of development, cyclical hormonal response and involution
- benign breast conditions are practically a universal phenomenon among women
- benign pathological states account for approximately 90% of the clinical presentations related to the breast
- these diseases are more common in females 30-50 years old, thus it is hormonal in nature
- previously there was a tendency to include all benign breast disorders and pathology under the designation of 'fibrocystic disease'
- this term, when applied to a biopsy or a palpable breast mass, is nonspecific and often includes normal physiologic and morphologic changes in the breast along with specific benign disease process.
- another term used in this regard is 'mammary dysplasia'
- purpose of the term ANDI is to refrain from calling normal changes a disease and to eliminate confusion
ANDI CLassification of benign breast disorders:
- disorders of development
- Polymastia and polythelia (exposed to the same scope of disease as normal breast tissue)
- Accessory axillary breast tissue
- Congenital inversion of nipples
- Macromastia
- Fibroadenoma
- Phylloides tumor
- Adolescent hypertrophy - gross stromal hyperplasia at time of development, of unknown origin
- disorders of cyclical change
- Mastalgia and nodularity
- disorders of involution
- Fibrocystic breast disease /fibrocystic change /chronic cystic mastitis /mammary dysphasia
- includes a variety of changes in the glandular and stromal tissue in response to the levels of oestrogen and prrogesterone and often presents with cyclical breast pain (mastalgia)
- Fibrocystic changes:
- Cysts
- Fibrosis
- Sclerosing adenosis
- Duct ectasia with periductal mastitis
- Fibrocystic breast disease /fibrocystic change /chronic cystic mastitis /mammary dysphasia
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